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Yes, continuous, long-term administration can lead to pituitary receptor desensitization, reducing the effectiveness of the peptides

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An overview of dietary l-carnitine metabolism in humans, its relationship to both BB and CVD risks, and the impact of preceding dietary pattern (omnivorous versus vegan/vegetarian), as well as chronic l-carnitine supplementation, as revealed by the present studies, are summarized in the scheme shown in Figure 10

A whole-cell electron tomography model of vacuole biogenesis in Arabidopsis root cells