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197 In the PI3K/Akt signaling pathway, PTEN can convert phosphatidylinositol 3,4,5-triphosphate (PIP3) to phosphatidylinositol 4.5-bisphosphate (PIP2), thereby preventing the phosphorylation of Akt, and then inhibiting the activation of PI3K/Akt/mTOR signaling pathway (Figure 8)

D+Q works by inhibiting pro-survival pathways (tyrosine kinases and Bcl-2 family) broadlythese pathways are also present in non-senescent cells, creating off-target effects