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This pathway intersects with cellular methylation balance and with NAD-related metabolism (NAD is a key cofactor used in energy production)

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then examined a cohort of 80 patients, split equally into 4 groupsone receiving lidocaine injections, one receiving 100 mg thiamine subcutaneously, one receiving 1000 g cobalamin B12 subcutaneously, and one receiving a combination of thiamine 100 mg and B12 1000 g subcutaneously

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