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FOXO4-DRI eliminated fibroblasts in G0/G1 phase cell cycle arrest and selectively induced senescent keloid cells apoptosis in an in vitro model of fibroblasts and organ culture In the serum limitation-induced senescent fibroblast model, more SA--gal-positive cells were observed in keloid fibroblasts compared with that in normal skin fibroblasts (Fig

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[25] In gastric cancers (GC), it has been observed that there were lower levels of FOXO4 mRNA in cancers that had already progressed to invading lymph nodes compared to cancers that remained in situ

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