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Several phytochemicals, including berberine and other isoquinoline alkaloids, inhibit the assembly and activation of NLRP3, reducing mature pro-inflammatory cytokine release and mitigating neuroinflammation and neuronal loss in PD models ( Beyond immunomodulation, many plant phytoconstituents exert antioxidant and mitochondrial protective effects that are crucial in neurodegeneration

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[DOI] [Google Scholar] 143.Mikus D., Sikiric P., Seiwerth S., Petricevic A., Aralica G., Druzijancic N., Rucman R., Petek M., Pigac B., Perovic D., et al

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