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NAD+ is also a cofactor for nonredox NAD+-dependent enzymes, including sirtuins, CD38, SARM1, poly (ADPribose) polymerase (PARP), ADPribosyltransferase (ART) and RNA polymerase, which are essential for the maintenance of intracellular homeostasis [84, 85]

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T helper 2 (TH2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production

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