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Conclusions: Semaglutide lowers cardiovascular risk in T2DM, primarily improving major adverse cardiovascular events, nonfatal myocardial infarction, and revascularization, with oral and subcutaneous forms demonstrating consistent efficacy

Ethical Approval SUSTAIN 6 and PIONEER 6 were approved by independent ethics committees and institutional review boards at each participating center and conducted in compliance with the International Conference on Harmonization Good Clinical Practice guidelines and the Declaration of Helsinki

It is also approved to treat noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate to advanced liver fibrosis

Life is all about balance, and that is especially true when it comes to diet

GI side effects are common during the initial weeks of treatment and usually improve over time