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When water freezes, it forms ice crystals

While it showed promise in preclinical studies and limited human trials, it was never advanced to late-stage clinical development or FDA approval

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Sci Rep 8(1):574

Among a variety of mechanisms, inflammation is characterized by the increase in the synthesis of positive acute phase proteins cytokines ( i.e ., haptoglobin, serum amyloid A) (Bertoni et al., 2008) and in the production of pro-inflammatory cytokines ( i.e ., IL-6, IL-1, TNF-) (Owen et al., 2013)