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P450 2E1 is the main isoenzyme involved in acetaminophen metabolism, but 1A2, 3A4, and 2A6 also contribute
The mechanism underlying the dopamine arrythmia may be dopamine signaling in cardiomyocytes, as activation of D1 in mouse cardiomyocytes is associated with ventricular arrythmia, which is mediated by calcium disruptions (Yamaguchi et al., 2020)
Acknowledgements The researchers extend their appreciation to Postgraduate Studies & Research Sector, Assiut University for funding this work as a research number: AUN2025F
GLP-1RA treatment upregulated mitochondrial proteins in skeletal muscle of the unimmobilized leg, including proteins involved in the aerobic electron transport chain and oxidative phosphorylation