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As a selective, reversible acetylcholinesterase inhibitor, Donepezil primarily enhances cholinergic neurotransmission, improving cognitive function in AD [93]

It was a moment of crisis where the old model became so burdened by anomalies that it was not merely updated, but overthrown

These included elevated levels of N -acetylarginine, indoxyl and indoxyl sulfate with decreased levels of methylguanidine, and several other compounds that remained unidentified over the course of the study

Food and Drug Administration, 2017

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