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Numerous studies have identified abnormal alterations in various cytokines in the CSF and peripheral blood of SZ patients (see Table 3 ), most of which are pro-inflammatory cytokines (IL-1, IL-2, IL-8, TNF-, and IFN-) (188191), with a smaller proportion being anti-inflammatory cytokines (including TGF-1, IL-4, and IL-10) (192)
As such, TGR5 activation stimulates secretion of GLP-1, while FXR activation reduces GLP-1 secretion, demonstrating a complex interplay between the differential bile acid pool composition and gutbrain signaling 270,271
Diabetes 62 (10), 35323541
Burch, Troy Griggs, Mika Grndahl, Lingdong Huang, Tim Wallace, Jeremy White, and Josh Williams (2021) What the Tulsa Race Massacre Destroyed. New York Times, May 24, 2021
10.1371/journal.pone.0137427 10.1371/journal.pone.0137427 [DOI] [PMC free article] [PubMed] [Google Scholar] Wang Y, Cao P, Alshwmi M et al (2019a) GPX2 suppression of H2O2 stress regulates cervical cancer metastasis and apoptosis via activation of the -catenin-WNT pathway
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