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Generally, the detection of increased serum levels of sugar derivatives, including gluconates [30], pyruvate, lactate, d-( +)-galacturonic acid and (myo-)inositol [31], 2,3-bisphosphoglyceric acid (2,3-BPG) and pentitol-3-desoxy [34], particularly in the first 24 h after TBI, corresponded to poorer clinical outcomes and increased mortality (Table 1)

Absorption improves with carbohydrate and protein, so timing supplements with balanced meals optimizes bioavailability

A certificate of analysis from a credentialed third-party lab (not just an in-house stamp) is the minimum standard