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Unlike traditional peptides, MOTS-c directly influences cellular metabolism by enhancing glucose uptake, increasing fatty acid oxidation, and supporting mitochondrial function

It's a pentapeptide (5 amino acids) that mimics ghrelin, creating natural GH spikes similar to youth

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Manipulations of Rac1 activity in the hippocampus using Rac1 inhibitor (NSC23766) and activator (CN04-A) were also reported to alter the maintenance of contextual fear memory in a similar fashion (Oh et al., 2010)

Simultaneously, Semax modulates dopamine D1 and D2 receptor density in the striatum, enhancing motivation and working memory without the tolerance development seen with direct dopamine agonists