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Trong qu trnh s dng Glutathione, bn nn lu nhng vn nh sau: Ngoi nhng tc dng mang li, Glutathione cng c th gy ra mt s tc dng ph cho ngi s dng: Theo nhiu nghin cu lm sng, tc dng ph xy ra c lin quan rt cht ch n liu lng Glutathione m ngi bnh s dng

PMID 28035768.

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CaMKK2 dysfunction may play an underlying role in this phenomenon as genetic deletion of Camkk2 in hippocampal neurons, myeloid cells and immortalized cell lines (HEK293 and HepG2) results in mitochondrial dysfunction that causes a similar switch in cellular energy generation from oxidative phosphorylation to glycolysis [43, 201, 202]