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This metabolic symbiosis exhibits biphasic regulation: LNCaP cells upregulate Gln catabolic pathways (e.g., GLS1-dependent glutaminolysis), while CAFs activate extracellular matrix (ECM) remodeling pathways

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Cardiac MRI showed no evidence of myocardial (T2* = 45.5 ms) or hepatic (T2* = 17.5 ms) iron overload and normal bi-ventricular size and function, with LVEF of 66% and normal right ventricular ejection fraction of 63%