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In this 40-week study, 1879 patients were randomly assigned, in a 1:1:1:1 ratio, to receive tirzepatide at a dose of 5 mg, 10 mg, or 15 mg or semaglutide at a dose of 1 mg per week

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Therefore, chronic stress-induced dysregulation of the HPA axis, potentially mediated by imbalances in gut microbiota, might be a crucial link between dysbiosis and the progression of AD (Figure 1)