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Indications and Usage: Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis

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Folic Acid Caution: High doses of folic acid can mask the blood-related symptoms of vitamin B12 deficiency, but do not protect against nerve damage

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however, there was also some indication that it induced greater cross-reactivity and durability of the immune response [149]