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Since high levels of GSTs are expressed in the hepatocytes and it has previously been demonstrated that GSTs display sulfonamidase activity, three sulfonamide prodrugs of metformin were designed and synthesized 120

1999;276:R15414

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Clinical Therapeutics, 33(10), 1413-1432

GLP-1 medications cause nausea primarily because they slow gastric emptying, meaning food stays in the stomach longer