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Insulin Resistance (If Misused Long-Term) Paradoxically, while IGF-1 LR3 can improve insulin sensitivity when used properly, chronic overuse may lead to receptor desensitization and eventual insulin resistance especially when paired with poor diet

In the treatment of breast cancer, anti-estrogen tamoxifen, the drug most often used for the long-term treatment of early breast cancer, can induce apoptosis in many cells, and this effect may be mediated by ROS generation in the mitochondria of breast cancer cells [71]

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This dual approach not only increases energy availability but also aids in weight management and body fat reduction, making it a potent combination for those looking to enhance body composition

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