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Interestingly, a few years ago it has been published that in flies missense mutations of the SLC25A39 homologue shawn results in accumulation of ROS as well as in mitochondrial dysfunction, synaptic defects, and neurodegeneration

Garvey, W

4 Future challenges 4.1 Mechanistic validation across ocular pathologies Despite progress in understanding molecular pathways such as calcium channel modulation and mitochondrial mitophagy, the relative contributions of these mechanisms to specific diseases remain unclear