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Cigarette Package Health Warnings report in English Cigarette Package Health Warnings report in French About the Canadian Cancer Society The Canadian Cancer Society works tirelessly to save and improve lives

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Studies of this phenomenon have shown that macrophages are activated by factors such as cigarette smoke extracts and release inflammatory mediators such as TNF-, CXCL1, CXCL8, CCL2, leukotriene (LT) B4 and reactive oxygen species (ROS), etc., which mediate the inflammatory response ( Figure 2 Macrophages have different phenotypes with different activation pathways that lead to different organismal responses