Recently, it has been clarified that autophagy can eliminate injured mitochondria while inducing biogenesis of new mitochondria, showing that the control of mitochondria number is not solely dependent on biogenesis, also giving a new interpretation for mitochondria control (Li A
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Titration phase (weeks 37) Participants in groups A and B will receive an active nicotine patch (21 mg/day) for the entire titration phase in addition to escalating doses of either active patches (group A) or placebo patches (group B) per the following dose titration protocol
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