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It is not a perfectly flat line a daily shot gives a broad peak then a decline but it is more sustained and less pulsatile than natural secretion, and it triggers IGF-1 and somatostatin feedback that dials your own pituitary down while treatment continues

However, different chromium formulations, dosages, treatment durations, baseline metabolic statuses, and cohort characteristics are probably responsible for the variable findings across trials

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The health consequences of excess visceral fat are well documented