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This effect was significantly blunted in 3-KO mice

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This is consistent with GHK-Cus known role in upregulating collagen synthesis in dermal fibroblasts, a mechanism confirmed in a comprehensive review in Biomolecules documenting GHK-Cus influence across more than 4,000 human genes involved in tissue remodeling and repair

Refer to Table 3: Treatment of B 12 deficiency for supplementation routes, dosage and duration

AMPK activation through MOTS-c increases glucose uptake in skeletal muscle, promotes fatty acid oxidation, and inhibits lipogenesis