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Although not proven, theories exist as to factors that influence IBS symptoms, including: neurological hyper-sensitivity within the GI (enteric) nerves physical and/or emotional stress dietary issues such as food allergies or sensitivities, or poor eating patterns use of systemic antibiotics for GI infection bile acid malabsorption the amount or pattern of physical exercise chronic alcohol abuse abnormalities in GI secretions and/or digestive muscle contractions (peristalsis) acute infection or inflammation of the intestine (enteritis), such as travellers diarrhea, which may precede onset of IBS symptoms The GI system is very sensitive to adrenalin the hormone released when one is excited, fearful, or anxious and to other hormones as well

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WHO addresses requests coming from Non-Parties and from Non-State actors

The growth of e-commerce channels makes it easier for consumers to access different lighter models, supporting continuous sales growth