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Treatment of mice with metabolic syndrome showed increased energy expenditure, enhanced fatty acid oxidation, decreased fat mass, and improved insulin sensitivityall without changes in food intake

Due to the heterogeneity in the clinical presentation of PCOS, two well-validated murine models of PCOS 37,46,70 were used

By combining incretin-mediated glucose regulation with glucagon-mediated lipid oxidation, multi-receptor agonists may help restore a more flexible metabolic state

R.et al (2013)

I think it's important to really understand that the people who are saying, "This medication is amazing and it changed my life," there's a self-selection bias here