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doi: 10.3748/WJG.V21.I2.484 271 GuanXStollBLuXTappendenKAHolstJJHartmannBet al

Specifically, TM6ECL3 is clasped by TM5 and TM7 and stabilized by hydrophobic interactions with TM3, TM5 and ECL2 via L349 6.48b , V352 6.51b , V355 6.54b , P359 6.58b and V360 6.59b , and by polar contacts with TM1, TM3 and TM7 via E354 6.53b , F357 6.56b , E363 ECL3 , Q364 ECL3 and A365 ECL3

In macrophages, silence of the SLC7A11 gene promotes iron overload-induced ferroptosis, suggesting that the TGF signaling pathway is crucial for regulating macrophage ferroptosis (80, 81)

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