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More males were enrolled in the placebo group (64.5%) and more females were enrolled in the treatment group (56.7%) but overall, there was no statistical difference (p = , 0.126)

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To ascertain whether plasma and liver FGF21 could act on endocrine pancreas, we analysed the single-cell RNA sequencing data of in vitro differentiation of beta cells [24] (available in the public database GSE114412)

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