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In a separate case series, researchers found that 8 patients with treatment-resistant depression also experienced dramatic improvement in their symptoms and functioning with chromium supplementation

This dose and time regiment was chosen as has been shown to be well-tolerated in mice while producing measurable biological effects on the mitochondria (Makowski et al., 2009

These results suggest that the experimental dosing strategy improved metabolic efficiency (as indicated by the lower RQ) and reduced mental and physical perception of effort