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2010 doi: 10.1038/333287d0

Future investigations should integrate longitudinal human cohorts with mechanistic animal studies colonized by smoker-derived microbiota, which may provide causal insight into how specific taxa or metabolites mediate disease trajectories

This ICD-10 code is only used when healthcare providers have surmised that a patient's past nicotine dependence has impacted them by contributing to whatever complication, disease like pulmonary edema, or chronic disease, like chronic obstructive pulmonary disease, they are currently dealing with, but the problem hasn't been identified

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