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MTHFR gene mutations have been found in medically reviewed studies to increase the risk of miscarriage and birth defects, including spina bifida

Hashimoto's thyroiditis is an autoimmune condition where your immune system produces antibodies, specifically thyroid peroxidase antibodies (TPO) and thyroglobulin antibodies (TgAb), that attack your thyroid tissue

But biology and real life rarely match a simple cause and effect, so human trials are essential to understand whether supplements move the needle

Normally distributed data were analysed by Students t test or ANOVA with Dunnetts multiple comparisons test, or one-sample t -test, as indicated in the figure legends