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It does not require a prescription in the traditional sense, but obtaining it through proper channels has become more difficult with the Category 2 classification
Inconsistent administration Skipping doses, irregular timing, and forgotten applications all reduce effectiveness
As shown in Figure 13, palmatine was docked into the PAS site of AChE (PDB ID = 4EY7) through hydrogen bonding, van der Waals interaction, PI donor hydrogen bonding, Pi-Pi Stacked, and Pi-Pi T-shaped, based on the molecular docking studies, more rational design and structural modification can be performed on the palmatine in the future research, thus enhancing its anti-AD effect