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It has been suggested that reperfusion increases reactive oxygen species (ROS) production which can have further deleterious consequences

The oral route of administration for GLP-1 does pose challenges due to the drugs high molecular weight, extremely low absorption with the commercially available oral tablets, and the drugs sensitivity to the heat required to compound it into a lozenge

Therefore, healthcare providers often recommend a careful tapering schedule when discontinuing the medication to minimize any adverse effects

My hunger has gone down and I feel fuller after eating less