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The body metabolizes nicotine primarily in the liver, converting it into cotinine, which can be measured to determine nicotine exposure

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This effect on blood clots is important because we know that in the long-term this can lead to clogged up and narrower blood vessels, and that of course puts people at risk of heart attacks and strokes. Jonathan Grigg, who was not involved in the research, is Chair of the European Respiratory Society Tobacco Control Committee and Professor of Paediatric Respiratory and Environmental Medicine at Queen Mary University of London, UK