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Anti-smoking advocates and health experts hailed the proposals as a bold effort to take on a habit that remains the leading preventable cause of death in a city that already has helped impose the highest cigarette taxes in the country, barred smoking in restaurants, bars, parks and beaches and launched sometimes graphic advertising campaigns about the effects of smoking

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Given the involvement of differential mtDNA methylation in various diseases and the critical involvement of mitochondrial dysfunction in COPD [30], the aim of the current study was to investigate in airway epithelial cells, whether the CSE-induced dysfunction in mitochondria and changes in mitochondrial gene expression are related to changes in mtDNA methylation

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