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MR helps mitigate confounding biases by leveraging the random allocation of genetic variants at conception and exclude reverse causation, as genetic determinants precede disease onset [26]

Nausea is the most commonly reported side effect, and antiemetic or prokinetic agents may be recommended for short-term use when it is severe or persistent

Approved patients receive notification via email and secure patient portal with next steps for medication fulfillment

the dimer interface comprises a central region, the hinge region that is important for the proper dimer formation and orientation

Notably, participants in the 12mg group had not reached a weight loss plateau at 48 weeks, suggesting that longer treatment durations could yield even greater reductions