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Second, the 39-residue chain length means lower overall synthesis yields compared to shorter peptides, because each coupling step has a less-than-perfect success rate that compounds across the chain

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More so, as stated in this 2019 study, "there is no established upper limit for vitamin B12 intake, as it has a low potential for toxicity." Although taking extremely high dosages of vitamin B12 is deemed safe, it is still not recommended to go above and beyond recommended vitamin B12 intake levels as mentioned above