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193 In addition, the relative contribution of these pathways and enzymes to NADPH production can be variable in different cell types and under different conditions

doi: 10.1158/0008-5472.Can-05-1107 216 JiQSMulvihillMJRosenfeld-FranklinMCookeAFengLMakGet al

They're naturally produced in the body and have been studied for their role in wound healing and tissue repair

Upon DNA damage, COP1 is inactivated through a process involving its dissociation from p53, ATM-mediated phosphorylation on COP1 S387, autoubiquitination and proteasome mediated degradation 30

High cost and limited accessibility may restrict widespread adoption, particularly in resource constrained healthcare systems