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G6PD inhibition has been shown to impair cellular migration through ROS-dependent inhibition of protein phosphatases involved in cytoskeletal rearrangement, suggesting that chronic ROS accumulation in G6PD-d may inhibit B1 migration necessary for IgM OSE production 87,144,145 (Fig

They were washed in PBS with PTx.2 (0.2% Triton X-100) for 2 1 h at room temperature

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These cells were further characterized as containing large (canine) to medium (human) solid round granules by electron microscopy and termed L-cells (11)