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Among studies analyzing risk and protective factors, as well as motives for EC use, arranged from lower to higher quality in study design, there is one case-control study 60 , one discrete choice experiment 63 , 18 cross-sectional studies 47,50-53,55-58,64,66,67,70,71,75,78,79,96 , 8 longitudinal studies 54,61,62,68,74,76,77,80 , and 2 randomized controlled trials 49,59
Currently, evidence for the safety, harmfulness, utility, and addictiveness of e-cigarettes is lacking
Spain's electronic cigarette regulatory laws are also set to become increasingly stringent
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