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No serious acromegaly, hypoglycemia, or excessive IGF1 elevations reported at recommended dosages (builtin negative feedback prevents overshooting)

Novo Nordisks presence as one of the top filers is unsurprising given its dominating role in the weight-loss drug market due to the proprietary status of Wegovy and Ozempic

A 2012 paper extended these findings into more detailed gastric-dysmotility investigations (PMID 27186127)

The Gut-Brain Axis and the Vagus Nerve The GLP-1 produced in the intestines after a meal also plays a role in suppressing eating, likely through different circuits than those GLP-1-expressing neurons found in the brain stem