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The semaglutide arm activates the GLP-1 receptor an incretin receptor expressed in the pancreas, gut and brain enhancing glucose-dependent insulin secretion, slowing gastric emptying and signaling satiety in hypothalamic appetite centers

Cross-linking changes compound these problems

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These recommendations consider the main clinical targets in PCOS (insulin resistance, lipid imbalance, hormonal dysfunction), the most effective dosages and durations, and the current level of supporting evidence