Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism
Sample sections were blocked in 5 % goat serum with 0.3 % Triton X-100 for 1 h at RT and then incubated overnight at 4 C with the following primary antibodies: mouse anti-GLP-1R (1:50, Santa Cruz, CA, USA), mouse anti-GLP-1(1:50, Santa Cruz, CA, USA), rabbit anti-Iba1 (1:500, Wako Chemicals, Tokyo, Japan), rabbit anti-GFAP (1:200, Cell Signalling, Boston, MA, USA), rabbit anti-NeuN (1:100, Proteintech, China), mouse anti-CGRP (1:100, Santa Cruz, CA, USA), and mouse anti-c-fos (1:100, Santa Cruz, CA, USA)
"Because what happens if you stop is, almost immediately, your blood pressure will become abnormal again
Tirzepatide is not indicated for type 1 diabetes and has not been established for use in pediatric patients
Generics and biosimilars could emerge after 2026, with legal battles and manufacturing challenges potentially delaying availability