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In contrast, in 3xTg males, CR-fed mice had upregulation of both pro-inflammatory ( Il1b and Il6 ) and anti-inflammatory ( Il10 ) genes compared to AL- and DL-fed groups (Fig

Figure 1 Potential for differentiation with small molecules Detailed investigation of the small molecule GLP-1 receptor agonist danuglipron showed that, compared to natural GLP-1, the synthetic agonist showed differences in GPCR coupling to the cAMP and B-arrestin downstream biological pathways