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These included four RCTs,478, 483, 484, 485 two post-hoc analyses of previous RCTs,245, 486 and two cohort studies.487, 488 The studies were primarily focused on evaluation of dual or poly-use of conventional cigarettes and other tobacco products (e-cigarettes, waterpipes, cigars)

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He said the decline in cigarette smoking is a tremendous public health gain. A lot of the health effects that are known to be caused by smoking, whether youre talking about cancer or cardiovascular risks, theyre very much dose dependent, Jorenby said