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The working model holds that high NNMT activity in fat tissue consumes nicotinamide and methyl donors in a way that favors fat storage over energy burn

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Aging 6 , 707717 (2014)

Yarasheski KE, Campbell JA, Smith K, Rennie MJ, Holloszy JO, Bier DM

(2) the limitation of using rodent models to explore in vivo UA mechanisms on diseases, since these species express uricase, (3) the restricted availability of research addressing the role of UA oxidation products, underscoring the importance of further explore this field