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Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes: systematic review and meta-analysis of randomised and observational studies

Developing purposeful maintenance strategies for patients is an opportunity to attract patients looking for not only effective treatments, but also ones they can tolerate and sustain results over time

(PubMed) Tangney CC, Tang Y, Evans DA, Morris MC

However, because Gallups method of collecting self-reported weight and height has been consistent, the trend still provides valuable information about change over time

However, Epithalon's promise comes with important caveats - most research conducted in Russia with limited Western validation, no FDA approval or large-scale international trials, long-term human safety data spanning years not decades, optimal dosing still based on Russian protocols rather than rigorous dose-finding studies, and mechanisms incompletely understood despite 40 years of research