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Many flavored e-liquids as well as flavoring chemicals used in e-liquids have been shown to be cytotoxic 6,7,8,9 , and the negative effects of nicotine-containing e-liquids in the lungs of animal models have been well documented by us and others 10,11,12,13,14

Methods: A comprehensive literature search was conducted in PubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure, and Wanfang Database for studies published up to 12 November 2025

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