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(2020) 318:H727

Clinically relevant to humans To evaluate the materials effectiveness in promoting cartilage growth, the investigators tested it in sheep with cartilage defects in the stifle joint, a complex joint in the hind limbs similar to the human knee

Quantitative measurements confirmed these observations, with FOXO4-DRI treatment significantly increasing voluntary running wheel activity in aged mice

These substances work through entirely different mechanisms and do not directly interfere with each other's pharmacological actions