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Key weight loss results [3] : Participants taking oral semaglutide lost about 16.6% of their starting body weight at 64 weeks (with full adherence) The placebo group lost only about 2.2% 28% of people lost 20% or more of their starting weight All participants followed a reducedcalorie diet and increased physical activity For comparison, onceweekly Wegovy 2.4 mg injections show about 16.9% mean weight loss in similar trials, suggesting that average weight loss is broadly comparable between the tablet and injection [4]

GI side effects may worsen, and clearance is unknown

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Recovery of one of these enzymes (ERp57) from oxidation required the presence of cytosol and, more specifically, GSH